Enhanced production of botrallin and TMC-264 with in situ macroporous resin adsorption in mycelial liquid culture of the endophytic fungus Hyalodendriella sp. Ponipodef12.
Identifieur interne : 002252 ( Main/Exploration ); précédent : 002251; suivant : 002253Enhanced production of botrallin and TMC-264 with in situ macroporous resin adsorption in mycelial liquid culture of the endophytic fungus Hyalodendriella sp. Ponipodef12.
Auteurs : Haiyu Luo [République populaire de Chine] ; Hongwei Liu [République populaire de Chine] ; Yuheng Cao [République populaire de Chine] ; Dan Xu [République populaire de Chine] ; Ziling Mao [République populaire de Chine] ; Yan Mou [République populaire de Chine] ; Jiajia Meng [République populaire de Chine] ; Daowan Lai [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Ligang Zhou [République populaire de Chine]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2014.
Descripteurs français
- KwdFr :
- Adsorption (MeSH), Ascomycota (croissance et développement), Ascomycota (métabolisme), Bioréacteurs (MeSH), Composés hétérocycliques 3 noyaux (isolement et purification), Composés hétérocycliques 3 noyaux (métabolisme), Mycelium (croissance et développement), Mycelium (métabolisme), Porosité (MeSH), Pyrones (isolement et purification), Pyrones (métabolisme), Résines synthétiques (composition chimique), Techniques de culture (MeSH).
- MESH :
- composition chimique : Résines synthétiques.
- croissance et développement : Ascomycota, Mycelium.
- isolement et purification : Composés hétérocycliques 3 noyaux, Pyrones.
- métabolisme : Ascomycota, Composés hétérocycliques 3 noyaux, Mycelium, Pyrones.
- Adsorption, Bioréacteurs, Porosité, Techniques de culture.
English descriptors
- KwdEn :
- Adsorption (MeSH), Ascomycota (growth & development), Ascomycota (metabolism), Bioreactors (MeSH), Culture Techniques (MeSH), Heterocyclic Compounds, 3-Ring (isolation & purification), Heterocyclic Compounds, 3-Ring (metabolism), Mycelium (growth & development), Mycelium (metabolism), Porosity (MeSH), Pyrones (isolation & purification), Pyrones (metabolism), Resins, Synthetic (chemistry).
- MESH :
- chemical , chemistry : Resins, Synthetic.
- chemical , isolation & purification : Heterocyclic Compounds, 3-Ring, Pyrones.
- growth & development : Ascomycota, Mycelium.
- metabolism : Ascomycota, Heterocyclic Compounds, 3-Ring, Mycelium, Pyrones.
- Adsorption, Bioreactors, Culture Techniques, Porosity.
Abstract
Hyalodendriella sp. Ponipodef12, an endophytic fungus from the hybrid "Neva" of Populus deltoides × P. nigra, is a high producer of the bioactive dibenzo-α-pyrones botrallin and TMC-264. However, both the botrallin and TMC-264 produced by Hyalodendriella sp. Ponipodef12 were retained as both intracellular and extracellular products. The aim of this study was to evaluate an in situ macroporous resin adsorption for enhancement of botrallin and TMC-264 production in mycelial liquid culture of Hyalodendriella sp. Ponipodef12. Production of botrallin and TMC-264 was most effectively enhanced by macroporous resin DM-301 among the thirteen nonionic macroporous resins tested. The highest botrallin yield (51.47 mg/L, which was 2.29-fold higher than the control at 22.49 mg/L) was obtained by adding resin DM-301 at 4.38% (g/mL) to the culture broth on day 24 and allowing a period of 4 days for adsorption. The highest TMC-264 yield reached 47.74 mg/L, which was 11.76-fold higher than that of the control (4.06 mg/L), and was achieved by adding DM-301 resin at 4.38% (w/v) in the culture broth on day 24 and allowing a period of 6 days for adsorption. The results show that in situ resin adsorption is an effective strategy for enhancing production of botrallin and TMC-264, and also for facilitating their recovery from mycelial liquid culture of Hyalodendriella sp. Ponipodef12.
DOI: 10.3390/molecules190914221
PubMed: 25211003
PubMed Central: PMC6271592
Affiliations:
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type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25211003</idno><idno type="pmid">25211003</idno><idno type="doi">10.3390/molecules190914221</idno><idno type="pmc">PMC6271592</idno><idno type="wicri:Area/Main/Corpus">002010</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002010</idno><idno type="wicri:Area/Main/Curation">002010</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002010</idno><idno type="wicri:Area/Main/Exploration">002010</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Enhanced production of botrallin and TMC-264 with in situ macroporous resin adsorption in mycelial liquid culture of the endophytic fungus Hyalodendriella sp. Ponipodef12.</title><author><name sortKey="Luo, Haiyu" sort="Luo, Haiyu" uniqKey="Luo H" first="Haiyu" last="Luo">Haiyu Luo</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. luohaiyu69@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Hongwei" sort="Liu, Hongwei" uniqKey="Liu H" first="Hongwei" last="Liu">Hongwei Liu</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. luohaiyu69@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, Yuheng" sort="Cao, Yuheng" uniqKey="Cao Y" first="Yuheng" last="Cao">Yuheng Cao</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. caoyuheng1990@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Dan" sort="Xu, Dan" uniqKey="Xu D" first="Dan" last="Xu">Dan Xu</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. cauxudan@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mao, Ziling" sort="Mao, Ziling" uniqKey="Mao Z" first="Ziling" last="Mao">Ziling Mao</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. maoziling2011@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mou, Yan" sort="Mou, Yan" uniqKey="Mou Y" first="Yan" last="Mou">Yan Mou</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. muyan01987@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Meng, Jiajia" sort="Meng, Jiajia" uniqKey="Meng J" first="Jiajia" last="Meng">Jiajia Meng</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. mengjiajiax@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lai, Daowan" sort="Lai, Daowan" uniqKey="Lai D" first="Daowan" last="Lai">Daowan Lai</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. dwlai@cau.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China. liuyang01@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Ligang" sort="Zhou, Ligang" uniqKey="Zhou L" first="Ligang" last="Zhou">Ligang Zhou</name><affiliation wicri:level="1"><nlm:affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. lgzhou@cau.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adsorption (MeSH)</term><term>Ascomycota (growth & development)</term><term>Ascomycota (metabolism)</term><term>Bioreactors (MeSH)</term><term>Culture Techniques (MeSH)</term><term>Heterocyclic Compounds, 3-Ring (isolation & purification)</term><term>Heterocyclic Compounds, 3-Ring (metabolism)</term><term>Mycelium (growth & development)</term><term>Mycelium (metabolism)</term><term>Porosity (MeSH)</term><term>Pyrones (isolation & purification)</term><term>Pyrones (metabolism)</term><term>Resins, Synthetic (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adsorption (MeSH)</term><term>Ascomycota (croissance et développement)</term><term>Ascomycota (métabolisme)</term><term>Bioréacteurs (MeSH)</term><term>Composés hétérocycliques 3 noyaux (isolement et purification)</term><term>Composés hétérocycliques 3 noyaux (métabolisme)</term><term>Mycelium (croissance et développement)</term><term>Mycelium (métabolisme)</term><term>Porosité (MeSH)</term><term>Pyrones (isolement et purification)</term><term>Pyrones (métabolisme)</term><term>Résines synthétiques (composition chimique)</term><term>Techniques de culture (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Resins, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Heterocyclic Compounds, 3-Ring</term><term>Pyrones</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Résines synthétiques</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Ascomycota</term><term>Mycelium</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Ascomycota</term><term>Mycelium</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Composés hétérocycliques 3 noyaux</term><term>Pyrones</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ascomycota</term><term>Heterocyclic Compounds, 3-Ring</term><term>Mycelium</term><term>Pyrones</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ascomycota</term><term>Composés hétérocycliques 3 noyaux</term><term>Mycelium</term><term>Pyrones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adsorption</term><term>Bioreactors</term><term>Culture Techniques</term><term>Porosity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adsorption</term><term>Bioréacteurs</term><term>Porosité</term><term>Techniques de culture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyalodendriella sp. Ponipodef12, an endophytic fungus from the hybrid "Neva" of Populus deltoides × P. nigra, is a high producer of the bioactive dibenzo-α-pyrones botrallin and TMC-264. However, both the botrallin and TMC-264 produced by Hyalodendriella sp. Ponipodef12 were retained as both intracellular and extracellular products. The aim of this study was to evaluate an in situ macroporous resin adsorption for enhancement of botrallin and TMC-264 production in mycelial liquid culture of Hyalodendriella sp. Ponipodef12. Production of botrallin and TMC-264 was most effectively enhanced by macroporous resin DM-301 among the thirteen nonionic macroporous resins tested. The highest botrallin yield (51.47 mg/L, which was 2.29-fold higher than the control at 22.49 mg/L) was obtained by adding resin DM-301 at 4.38% (g/mL) to the culture broth on day 24 and allowing a period of 4 days for adsorption. The highest TMC-264 yield reached 47.74 mg/L, which was 11.76-fold higher than that of the control (4.06 mg/L), and was achieved by adding DM-301 resin at 4.38% (w/v) in the culture broth on day 24 and allowing a period of 6 days for adsorption. The results show that in situ resin adsorption is an effective strategy for enhancing production of botrallin and TMC-264, and also for facilitating their recovery from mycelial liquid culture of Hyalodendriella sp. Ponipodef12. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25211003</PMID><DateCompleted><Year>2015</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>9</Issue><PubDate><Year>2014</Year><Month>Sep</Month><Day>10</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Enhanced production of botrallin and TMC-264 with in situ macroporous resin adsorption in mycelial liquid culture of the endophytic fungus Hyalodendriella sp. Ponipodef12.</ArticleTitle><Pagination><MedlinePgn>14221-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules190914221</ELocationID><Abstract><AbstractText>Hyalodendriella sp. Ponipodef12, an endophytic fungus from the hybrid "Neva" of Populus deltoides × P. nigra, is a high producer of the bioactive dibenzo-α-pyrones botrallin and TMC-264. However, both the botrallin and TMC-264 produced by Hyalodendriella sp. Ponipodef12 were retained as both intracellular and extracellular products. The aim of this study was to evaluate an in situ macroporous resin adsorption for enhancement of botrallin and TMC-264 production in mycelial liquid culture of Hyalodendriella sp. Ponipodef12. Production of botrallin and TMC-264 was most effectively enhanced by macroporous resin DM-301 among the thirteen nonionic macroporous resins tested. The highest botrallin yield (51.47 mg/L, which was 2.29-fold higher than the control at 22.49 mg/L) was obtained by adding resin DM-301 at 4.38% (g/mL) to the culture broth on day 24 and allowing a period of 4 days for adsorption. The highest TMC-264 yield reached 47.74 mg/L, which was 11.76-fold higher than that of the control (4.06 mg/L), and was achieved by adding DM-301 resin at 4.38% (w/v) in the culture broth on day 24 and allowing a period of 6 days for adsorption. The results show that in situ resin adsorption is an effective strategy for enhancing production of botrallin and TMC-264, and also for facilitating their recovery from mycelial liquid culture of Hyalodendriella sp. Ponipodef12. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Haiyu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. luohaiyu69@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hongwei</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. luohaiyu69@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Yuheng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. caoyuheng1990@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. cauxudan@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Ziling</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. maoziling2011@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mou</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. muyan01987@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Jiajia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. mengjiajiax@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Daowan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. dwlai@cau.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China. liuyang01@caas.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Ligang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China. lgzhou@cau.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006575">Heterocyclic Compounds, 3-Ring</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011753">Pyrones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012117">Resins, Synthetic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C476504">TMC-264</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000598261">botrallin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000327" MajorTopicYN="N">Adsorption</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001203" MajorTopicYN="N">Ascomycota</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019149" MajorTopicYN="N">Bioreactors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046508" MajorTopicYN="N">Culture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006575" MajorTopicYN="N">Heterocyclic Compounds, 3-Ring</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025282" MajorTopicYN="N">Mycelium</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000378" 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Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Luo, Haiyu" sort="Luo, Haiyu" uniqKey="Luo H" first="Haiyu" last="Luo">Haiyu Luo</name></noRegion><name sortKey="Cao, Yuheng" sort="Cao, Yuheng" uniqKey="Cao Y" first="Yuheng" last="Cao">Yuheng Cao</name><name sortKey="Lai, Daowan" sort="Lai, Daowan" uniqKey="Lai D" first="Daowan" last="Lai">Daowan Lai</name><name sortKey="Liu, Hongwei" sort="Liu, Hongwei" uniqKey="Liu H" first="Hongwei" last="Liu">Hongwei Liu</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Mao, Ziling" sort="Mao, Ziling" uniqKey="Mao Z" first="Ziling" last="Mao">Ziling Mao</name><name sortKey="Meng, Jiajia" sort="Meng, Jiajia" uniqKey="Meng J" first="Jiajia" last="Meng">Jiajia Meng</name><name sortKey="Mou, Yan" sort="Mou, Yan" uniqKey="Mou Y" first="Yan" last="Mou">Yan Mou</name><name sortKey="Xu, Dan" sort="Xu, Dan" uniqKey="Xu D" first="Dan" last="Xu">Dan Xu</name><name sortKey="Zhou, Ligang" sort="Zhou, Ligang" uniqKey="Zhou L" first="Ligang" last="Zhou">Ligang Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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